The biological sciences study (bio)complex living systems. Research directed at the mechanistic explanation of the "live" state truly requires a pluralist research program, i.e. BioComplexity research. The program should apply multiple intra-level and inter-level theories and methodologies. We substantiate this thesis with analysis of BioComplexity: metabolic and modular control analysis of metabolic pathways, emergence of oscillations, and the analysis of the functioning of glycolysis.

Union with Christ was a key doctrine for second-generation Reformed theologian Girolamo Zanchi. As a Thomist, Zanchi shared similar elements with Thomas Aquinas in his understanding of salvation as participatio, but his understanding of union with Christ differed with regard to the difference between infused and imputed righteousness. Unlike Aquinas’s doctrine of infused righteousness, Zanchi argued for imputed righteousness, which was both the foundation for one’s justification in this life as well as appearing before the divine bar at the final (...) judgment. Zanchi’s doctrine of union with Christ has the utmost significance for personal eschatology and the judgment believers undergo at the great assize, insights that are worth retrieving for a clear understanding of the relationship between justification and the final judgement. (shrink)

The current rise in malpractice litigation has led to concern in the research community as to the prospect of litigation against researchers. Clearly as the responsibility for the day-to-day conduct of the research falls upon the researchers they will be potentially liable should there be negligence in the conduct of the research project itself. But to what extent can the research ethics committee and its members be held liable should harm result to the research subject? How far does the prospect (...) of the threat of litigation equate with the reality of the prospect of liability? Although the NHS research governance framework suggests that primary responsibility for the conduct of the trial is with the researcher this does not mean that REC members will be immune from actions in tort where research subjects suffer harm in the conduct of a research project approved by their NHS REC. This paper focuses upon the prospect for liability in the law of tort of NHS RECs and their members. While in practice the vast majority of such claims are unlikely to be successful members of RECs may incur resultant legal costs as a consequence of involvement in proposed litigation. It is submitted that the scope of indemnity provision provided to RECs and their members should be precisely determined, otherwise there is a real prospect that the risk of malpractice litigation may deter individuals from serving on such committees. (shrink)

This long and complicated sentence has not been correctly translated nor clearly explained by any of the editors of the Phaedo that I have been able to consult. Bekker, Stallbaum, Wohlrab, Geddes, Wagner, Archer-Hind, Williamson, Burnet, in their notes on the passage say much that is true, but all seem to fall into certain errors. None of them has given an accurate and coherent picture of the passage as a whole. In attempting to supply such a picture I have pointed (...) out what I believe to be the mistakes of these editors, and on certain points of grammar, textual criticism, and interpretation I have some new suggestions to offer. So much emphasis on one sentence is not misplaced, for this is an important sentence, the culminating point of the first section of the dialogue, and containing in brief the essence of the ethics which Plato expounds through the mouth of Socrates. It is the peroration of Socrates' Apologia pro Vita sua, introduced by the impressive words: ⋯ μακ⋯ριε ειμμ^iota;α, a form of address often used by Socrates in passages of ‘pith and moment’. (shrink)

Felicitas Goodman (1990) observed that naive participants experienced unique trance states, characterized by specific visionary content, when they assumed particular postures and listened to monotonous rattling. Students (n = 284), enrolled in various sections of the course Introduction to Psychology, experienced one of four conditions with their eyes closed: Sitting Quietly with and without Drumming, Standing (Feather Serpent) Posture plus Drumming with and without Suggested Experiences. Participants completed the Phenomenology of Consciousness Inventory (Pekala 1982, 1991c) and wrote narratives following their (...) respective stimulus conditions. Participants reported less imagery, joy, and absorption, but more internal dialogue, self‐awareness, and muscular tension in the posture, compared to the sitting quietly, conditions. Goodman's results of specific posture (content‐related) effects with naive participants were not replicated. (shrink)

In the paper, the multilevel concept of methodology of science is reviewed. The author distinguishes five levels in the methodology of science. These levels vary in degree of generality and the nature of the relationship with philosophy. The first, most general level of the methodology of ways of learning of the studies on the application of science to philosophical methods such as dialectical and metaphysical. The doctrine of general scientific ways of knowing is the second, less common level of methodology (...) of science. The essence of scientific methods is studied at this level, given their theoretical rationale. There are heuristic dignity, epistemological possibilities, and the boundaries of applicability are identified. The third level of the methodology of science is the study of the system of general scientific ways of learning applied in any basic science. In addition to knowledge of the essence of these methods for the researcher requires knowledge of the basic problems of this science. The fourth level of the methodology of science is the study of the system of general scientific ways of learning and epistemological problems in any basic science. The fifth level of the methodology of science are the problems of narrower plan. This study questions the use of certain, specific methods of scientific learning. Thus, the methodology of science is complex and has a complicated structure. The two most general level the methodology are philosophical, the next two are common to philosophy and science, the fifth level is of a specifically scientific nature. (shrink)